{"id":556,"date":"2023-11-30T17:33:00","date_gmt":"2023-11-30T17:33:00","guid":{"rendered":"https:\/\/cellandcelldivision.com\/?p=556"},"modified":"2024-02-08T00:19:07","modified_gmt":"2024-02-08T00:19:07","slug":"page-115","status":"publish","type":"post","link":"https:\/\/cellandcelldivision.com\/?p=556","title":{"rendered":"Page 115"},"content":{"rendered":"\n<p class=\"has-text-align-center\">themselves in the replication of the chromosome in a non-random fashion, thus<br>being handed down from one cell generation into another (just like DNA), which<br>is in accordance with the idea of Tsanev and Sendov (1971) that the specific<br>arrangements of histones along the DNA-chain are kept up during the replication<br>by specific interactions between the previously existing DNA-bound histones<br>and the newly-synthesized free histones. Some authors would not agree with<br>this assertion (Jackson et al., 1975, 1976; Seale, 1976). According to them<br>histones are randomly distributed upon the self-replicating chromosomes. This is<br>a serious scientific disagreement. The importance of this problem requires a<br>definitive solution, which is related to further investigations. More plausible,<br>however, seems from a general biology standpoint the thesis supporting the<br>non-random i.e. conservative distribution of histones on both DNA-chains.<br>The established by Chentsov and Poljakov (1970) presence of an<br>especially dense substance in the metaphase and telophase chromosomes<br>distinguished for its density from the surrounding cytoplasm and chromatin,<br>called <strong>matrix<\/strong> deserves no less attention (Fig. 2\u201345). According to Baskin<br>(1995) nuclear matrix is the key to gene expression.<\/p>\n\n\n\n<p>image<\/p>\n\n\n\n<pre class=\"wp-block-verse has-text-align-center\">Figure 2\u201345. Matrix in metaphase and telophase chromosomes (After \nChentsov and Poljakov, 1970). \na \u2014 metaphase chromosome after processing the cells with 0.2% of \nCoCl\u2082 solution; b \u2014 telophase chromosome surrounded by matrix. \nM \u2014 matrix<\/pre>\n\n\n\n<p class=\"has-text-align-center\">By the help of the methods for differential staining of chromosomes the<br>existence of two fractions of chromatin \u2014 heterochromatin and euchromatin<br>\u2014 was proven (Fig. 2\u201346). They differ in a number of qualities and<br>properties. Heterochromatin remains condensed during the entire interphase<br>and preserves its capacity for an intense staining, which is typical of<br>metaphase chromosomes. Brown (1966) has arrived at the conclusion about<br>the existence of two heterochromatin types \u2014 structural and facultative. In<\/p>\n","protected":false},"excerpt":{"rendered":"<p>themselves in the replication of the chromosome in a non-random fashion, thusbeing handed down from one cell generation into another (just like DNA), whichis in accordance with the idea of Tsanev and Sendov (1971) that the specificarrangements of histones along the DNA-chain are kept up during the replicationby specific interactions between the previously existing DNA-bound [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[6],"tags":[],"class_list":["post-556","post","type-post","status-publish","format-standard","hentry","category-book"],"_links":{"self":[{"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/posts\/556","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=556"}],"version-history":[{"count":1,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/posts\/556\/revisions"}],"predecessor-version":[{"id":618,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=\/wp\/v2\/posts\/556\/revisions\/618"}],"wp:attachment":[{"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=556"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=556"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cellandcelldivision.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=556"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}